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Are low levels of serum bicarbonate associated with risk of progressing to impaired fasting glucose/diabetes? A single-centre prospective cohort study in Beijing, China
- Source :
- BMJ Open
- Publication Year :
- 2018
-
Abstract
- AimsBicarbonate is involved in many human essential metabolic processes, but little is known about the association between serum bicarbonate and glucose metabolism. This study aims to investigate the association between serum bicarbonate and the risk of progressing to impaired fasting glucose (IFG)/diabetes mellitus (DM).SettingThe data were obtained from a large-scale prospective cohort study in a single health centre in Beijing.ParticipantsA total of 5318 participants aged 18–70 years who underwent health examinations annually with baseline fasting plasma glucose (FPG) ranging from 3.9 to 5.5 mmol/L, without a history of either diabetes or concomitant chronic diseases, were enrolled in this 6-year observational study.Primary outcome measuresA logistic regression analysis was used to calculate ORs for progressing to IFG/DM by the category of baseline serum bicarbonate. In addition, an analysis of the receiver operating characteristic (ROC) curve for predicting IFG was performed.ResultsOf the 5318 participants, 210 developed IFG after a median 2.2 years of follow-up. After adjusting for sex, age, FPG, body mass index, systolic blood pressure, serum creatinine, serum alanine aminotransferase and low-density lipoprotein cholesterol at baseline, the participants in the first (OR 4.18, 95% CI 2.42 to 7.21; pConclusionsLower serum bicarbonate is associated with higher risk of the development of IFG/DM.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
China
Bicarbonate
030209 endocrinology & metabolism
bicarbonate
Prediabetic State
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Insulin resistance
impaired fasting glucose
Internal medicine
Diabetes mellitus
insulin resistance
medicine
Humans
Longitudinal Studies
Prospective Studies
Prospective cohort study
Creatinine
business.industry
Research
General Medicine
Glucose Tolerance Test
medicine.disease
Impaired fasting glucose
Bicarbonates
Diabetes and Endocrinology
030104 developmental biology
Blood pressure
Logistic Models
chemistry
Diabetes Mellitus, Type 2
ROC Curve
Disease Progression
Female
business
Body mass index
Subjects
Details
- ISSN :
- 20446055
- Volume :
- 8
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- BMJ open
- Accession number :
- edsair.doi.dedup.....76ca4d497f6db1ed7737b4cf8a9ed810