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Structure and Function of Heterotrimeric G Protein-Regulated Rho Guanine Nucleotide Exchange Factors
- Source :
- Molecular Pharmacology. 77:111-125
- Publication Year :
- 2009
- Publisher :
- American Society for Pharmacology & Experimental Therapeutics (ASPET), 2009.
-
Abstract
- Activation of certain classes of G protein-coupled receptors (GPCRs) can lead to alterations in the actin cytoskeleton, gene transcription, cell transformation, and other processes that are known to be regulated by Rho family small-molecular-weight GTPases. Although these responses can occur indirectly via cross-talk from canonical heterotrimeric G protein cascades, it has recently been demonstrated that Dbl family Rho guanine nucleotide exchange factors (RhoGEFs) can serve as the direct downstream effectors of heterotrimeric G proteins. Heterotrimeric Galpha(12/13), Galpha(q), and Gbetagamma subunits are each now known to directly bind and regulate RhoGEFs. Atomic structures have recently been determined for several of these RhoGEFs and their G protein complexes, providing fresh insight into the molecular mechanisms of signal transduction between GPCRs and small molecular weight G proteins. This review covers what is currently known about the structure, function, and regulation of these recently recognized effectors of heterotrimeric G proteins.
- Subjects :
- Pharmacology
GTPase-activating protein
G protein
Minireviews
macromolecular substances
GTPase
Biology
Heterotrimeric GTP-Binding Proteins
Receptors, G-Protein-Coupled
Cell biology
G beta-gamma complex
Biochemistry
Heterotrimeric G protein
G12/G13 alpha subunits
Animals
Guanine Nucleotide Exchange Factors
Humans
Molecular Medicine
Rho Guanine Nucleotide Exchange Factors
Signal Transduction
G protein-coupled receptor
G alpha subunit
Subjects
Details
- ISSN :
- 15210111 and 0026895X
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- Molecular Pharmacology
- Accession number :
- edsair.doi.dedup.....76c21923e3741d4e33d22608fc72c95a