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Kidney allograft fibrosis: what we learned from latest translational research studies
- Source :
- Journal of Nephrology. 33:1201-1211
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- To add new molecular and pathogenetic insights into the biological machinery associated to kidney allograft fibrosis is a major research target in nephrology and organ transplant translational medicine. Interstitial fibrosis associated to tubular atrophy (IF/TA) is, in fact, an inevitable and progressive process that occurs in almost every type of chronic allograft injury (particularly in grafts from expanded criteria donors) characterized by profound remodeling and excessive production/deposition of fibrillar extracellular matrix (ECM) with a great clinical impact. IF/TA is detectable in more than 50% of kidney allografts at 2 years. However, although well studied, the complete cellular/biological network associated with IF/TA is only partially evaluated. In the last few years, then, thanks to the introduction of new biomolecular technologies, inflammation in scarred/fibrotic parenchyma areas (recently acknowledged by the BANFF classification) has been recognized as a pivotal element able to accelerate the onset and development of the allograft chronic damage. Therefore, in this review, we focused on some new pathogenetic elements involved in graft fibrosis (including epithelial/endothelial to mesenchymal transition, oxidative stress, activation of Wnt and Hedgehog signaling pathways, fatty acids oxidation and cellular senescence) that, in our opinion, could become in future good candidates as potential biomarkers and therapeutic targets.
- Subjects :
- Graft Rejection
Nephrology
medicine.medical_specialty
hedgehog signaling pathways
Wnt pathway
030232 urology & nephrology
Inflammation
030204 cardiovascular system & hematology
Kidney
Cellular senescence
Organ transplantation
Fatty acids oxidation
Interstitial fibrosis and tubular atrophy
Kidney fibrosis
Translational Research, Biomedical
Extracellular matrix
03 medical and health sciences
0302 clinical medicine
Fibrosis
Internal medicine
Humans
Medicine
Hedgehog Proteins
business.industry
Mesenchymal stem cell
Wnt signaling pathway
Allografts
medicine.disease
Kidney Transplantation
Kidney Tubules
medicine.anatomical_structure
Cancer research
Atrophy
medicine.symptom
business
Subjects
Details
- ISSN :
- 17246059 and 11218428
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Journal of Nephrology
- Accession number :
- edsair.doi.dedup.....76c17a79a41a06e1421f40b874f1e4b1