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Bloodstream Infections in Children With Cancer: Pathogen Distribution and Antimicrobial Susceptibility Patterns Over a 10-Year Period
- Source :
- Maarbjerg, S F, Kiefer, L V, Albertsen, B K, Schrøder, H & Wang, M 2022, ' Bloodstream Infections in Children With Cancer : Pathogen Distribution and Antimicrobial Susceptibility Patterns Over a 10-Year Period ', Journal of Pediatric Hematology/Oncology, vol. 44, no. 1, pp. E160-E167 . https://doi.org/10.1097/MPH.0000000000002258
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Bloodstream infections (BSIs) adversely affect clinical outcome in children with cancer. Over 1 decade, this retrospective cohort study describes pathogen distribution in BSIs and antimicrobial susceptibility against empirical antibiotics frequently prescribed in children with cancer. The antibiotic efficacy was evaluated through the determination of minimal inhibitory concentrations for piperacillin-tazobactam and meropenem and by disk diffusion for remaining antibiotics. From 2004 to 2013, 398 BSIs occurred in 196 children with cancer (median age: 5.4 y), resulting in 457 bacteria. Overall, 266 (58.2%) were gram-positive, and 191 (41.8%) were gram-negative with a significant gram-positive increase over time (P=0.032). Coagulase-negative staphylococci (74, 16.2%), viridans group streptococci (67, 14.7%), Escherichia coli (52, 11.4%), and Staphylococcus aureus (39, 8.5%) were the most common pathogens. Susceptibility to piperacillin-tazobactam (95.9%, P=0.419) and meropenem (98.9%, P=0.752) was stable over time, and resistance was observed among viridans group streptococci against piperacillin-tazobactam (18%) and meropenem (7%) and among Enterobacterales against piperacillin-tazobactam (3%). Vancomycin showed 98% gram-positive activity, gentamicin 82% gram-negative activity and ampicillin, cefotaxime, and cefuroxime were active in 50%, 72%, and 69% of pathogens, respectively, and BSI-related mortality was 0%. In conclusion, over 1 decade, we report an increase in gram-positive BSIs, and stable, low-resistance rates against currently recommended empirical antibiotics, piperacillin-tazobactam and meropenem.
- Subjects :
- Male
medicine.medical_specialty
Cefotaxime
Adolescent
medicine.drug_class
Febrile neutropenia
Antibiotics
Microbial Sensitivity Tests
Bloodstream infection
medicine.disease_cause
Antimicrobial susceptibility
Meropenem
Antimicrobial therapy
Neoplasms
Sepsis
Ampicillin
Internal medicine
polycyclic compounds
medicine
Humans
Prospective Studies
Child
Bacteria
business.industry
Infant, Newborn
Infant
Bacterial Infections
Hematology
bacterial infections and mycoses
Pathogen distribution
Anti-Bacterial Agents
Piperacillin, Tazobactam Drug Combination
Oncology
Staphylococcus aureus
Child, Preschool
Pediatrics, Perinatology and Child Health
Vancomycin
Female
Gentamicin
business
Cefuroxime
medicine.drug
Subjects
Details
- ISSN :
- 10774114
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Hematology/Oncology
- Accession number :
- edsair.doi.dedup.....76bf1b091ad942a8f26e800a7e0b7e9a