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A comparison of host response strategies to distinguish bacterial and viral infection
- Source :
- PLoS ONE, PLoS ONE, Vol 16, Iss 12, p e0261385 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Objectives Compare three host response strategies to distinguish bacterial and viral etiologies of acute respiratory illness (ARI). Methods In this observational cohort study, procalcitonin, a 3-protein panel (CRP, IP-10, TRAIL), and a host gene expression mRNA panel were measured in 286 subjects with ARI from four emergency departments. Multinomial logistic regression and leave-one-out cross validation were used to evaluate the protein and mRNA tests. Results The mRNA panel performed better than alternative strategies to identify bacterial infection: AUC 0.93 vs. 0.83 for the protein panel and 0.84 for procalcitonin (P Conclusions A gene expression signature was the most accurate host response strategy for classifying subjects with bacterial, viral, or non-infectious ARI.
- Subjects :
- Bacterial Diseases
Male
Etiology
Gene Expression
Pathology and Laboratory Medicine
Biochemistry
TNF-Related Apoptosis-Inducing Ligand
Medical Conditions
Medicine and Health Sciences
Receptors, Immunologic
Respiratory Tract Infections
Virus Testing
Multidisciplinary
Bacterial Infections
Middle Aged
C-Reactive Proteins
Prognosis
Bacterial Pathogens
Infectious Diseases
C-Reactive Protein
Medical Microbiology
Virus Diseases
Viruses
Medicine
Female
Pathogens
Emergency Service, Hospital
Procalcitonin
Research Article
Adult
Science
Microbiology
Diagnosis, Differential
Diagnostic Medicine
Virology
Genetics
Humans
Microbial Pathogens
Retrospective Studies
Bacteria
Biology and Life Sciences
Proteins
United States
Chemokine CXCL10
ROC Curve
Case-Control Studies
Biomarkers
Viral Transmission and Infection
Follow-Up Studies
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....76bea1dddb72915058408097c424d2c5