Back to Search
Start Over
Cutting edge: IFN-γ regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection
- Source :
- Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, Scopus-Elsevier
- Publication Year :
- 2006
- Publisher :
- American Association of Immunologists, 2006.
-
Abstract
- T cell responses are important to the control of infection but are deleterious if not regulated. IFN-γ-deficient mice infected with mycobacteria exhibit enhanced accumulation of activated effector T cells and neutrophils within granulomatous lesions. These cells do not control bacterial growth and compromise the integrity of the infected tissue. We show that IFN-γ-deficient mice have increased numbers of IL-17-producing T cells following infection with Mycobacterium bovis bacille Calmette Gue´rin. Furthermore, exogenous IFN-γ increases IL-12 and decreases IL-23 production by bacille Calmette Gue´rin-infected bone marrow-derived dendritic cells and reduces the frequency of IL-17-producing T cells induced by these bone marrow-derived dendritic cells. These data support the hypothesis that, during mycobacterial infection, both IFN-γ- and IL-17-producing T cells are induced, but that IFN-γ serves to limit the IL-17-producing T cell population. This counterregulation pathway may be an important factor in limiting mycobacterially associated immune- mediated pathology.<br />Fundacão para a Ciência e Tecnologia (FCT) - grant SFRH/BD/9624/2002
- Subjects :
- CD4-Positive T-Lymphocytes
Male
T cell
Immunology
Mice, Transgenic
Biology
Interleukin-23
Microbiology
Interferon-gamma
Mice
03 medical and health sciences
Interleukin 21
0302 clinical medicine
medicine
Animals
Tuberculosis
Immunology and Allergy
Cytotoxic T cell
IL-2 receptor
Antigen-presenting cell
Cells, Cultured
Cell Proliferation
030304 developmental biology
Interleukin 3
Mice, Knockout
0303 health sciences
Science & Technology
Interleukins
Interleukin-17
Cell Differentiation
Dendritic Cells
CD4 T Cells
Natural killer T cell
Interleukin-12
Mycobacterium bovis
Growth Inhibitors
3. Good health
Mice, Inbred C57BL
IL-17
medicine.anatomical_structure
Interleukin-23 Subunit p19
Interleukin 12
Mycobacterial Infection
IFN-alpha
030215 immunology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....76b2b2cbc714a6652c60a2f64c7bc382