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High-dose paclitaxel plus G-CSF for malignant mesothelioma: CALGB phase II study 9234
- Source :
- Annals of Oncology. 10:597-600
- Publication Year :
- 1999
- Publisher :
- Elsevier BV, 1999.
-
Abstract
- Summary Background: New agents with activity in mesothelioma are sorely needed. The Cancer and Leukemia Group B (CALGB) therefore performed a phase II study of high-dose paclitaxel in patients with malignant mesothelioma who had no prior chemotherapy. Patients and methods: Thirty-five patients accrued to this multi-institutional phase II study of paclitaxel given as a 24hour infusion at 250 mg/m 2 every three weeks plus filgrastim (G-CSF) 300 meg subcutaneously days 3-18. Results: There were three (9%) regressions of evaluable disease. The median survival was five months (95% confidence interval (95% CI): 1.9-9.6 months), the one-year survival rate was 14% and the two-year survival rate was 6%. Toxicity was tolerable with one death from pneumonia (without neutropenia) on day 18 and a 23% rate of grade 4 granulocytopenia. Conclusions: The level of activity seen with paclitaxel is similar to that seen in other CALGB trials of the single agents carboplatin, trimetrexate and 5-azacytidine. Future studies of of paclitaxel (at lower doses) in combination with synergistic agents could be considered.
- Subjects :
- Adult
Male
Mesothelioma
Oncology
medicine.medical_specialty
Paclitaxel
medicine.medical_treatment
Phases of clinical research
Filgrastim
Neutropenia
chemistry.chemical_compound
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Granulocyte Colony-Stimulating Factor
Humans
Medicine
Survival rate
Aged
Chemotherapy
business.industry
Hematology
Middle Aged
medicine.disease
Carboplatin
Surgery
Survival Rate
chemistry
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 09237534
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Annals of Oncology
- Accession number :
- edsair.doi.dedup.....76a9c14d4d5ca1832d529966da3b13f8