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Early feeding and risk of Juvenile idiopathic arthritis: a case control study in a prospective birth cohort
- Source :
- Pediatric Rheumatology Online Journal, Pediatric Rheumatology Online Journal, Vol 15, Iss 1, Pp 1-9 (2017)
- Publication Year :
- 2017
- Publisher :
- BioMed Central, 2017.
-
Abstract
- Background: Juvenile idiopathic arthritis (JIA) is considered to be an autoimmune disease, but the etiology is unknown. We decided to study the influence of early nutrition on later development of JIA. Methods: All parents with children born between October 1, 1997 and October 1, 1999 in Southeast Sweden were asked to participate in the ABIS prospective cohort study (All Babies in Southeast Sweden), At 1 year, questionnaires with information on breastfeeding and introduction of foods were completed by 10,565 families. We identified 32 children with JIA and 111 children with non-chronic arthritis with completed questionnaires after delivery and after 1 year. A multivariable logistic regression model, adjusted for relevant factors, was performed to calculate the association between JIA and feeding during the first year of life. Results: An increased risk for JIA was found in children who had breast fed for less than 4 months, as opposed to those who were continued on breast milk beyond 4 months of age (aOR 3.5, 95% CI 1.4-8,5; p = 0.006). A short duration of exclusive as well as total breastfeeding was associated with an increased risk of JIA (aOR 1.3, 95% CI 1.1-1.6; p = 0.008 and aOR 1.2, 95% CI 1.1-1.3; p amp;lt; 0.001). All associations between breastfeeding and JIA persisted after adjustment. There was no relationship between early nutrition and non-chronic arthritis. Conclusions: Our results indicate that there are different disease mechanisms for different types of arthritis in childhood. Longer duration of breastfeeding (both total and exclusive) may protect against development of JIA. Mothers should be encouraged to breast-feed their babies exclusively, if at all possible, for 4 months and continue partial breastfeeding for an extended time when foreign proteins are introduced. Funding Agencies|Research Unit of Kalmar County Council; Swedish Rheumatism Association; Jerring Foundation; Swedish Child Diabetes Foundation (Barndiabetesfonden); Juvenile Diabetes Research Foundation; Medical Research Council of Southeast Sweden (FORSS)
- Subjects :
- Male
Pediatrics
lcsh:Diseases of the musculoskeletal system
Time Factors
Epidemiology
Breastfeeding
Arthritis
Autoimmunity
0302 clinical medicine
Reactive arthritis
Risk Factors
Surveys and Questionnaires
Immunology and Allergy
030212 general & internal medicine
Prospective cohort study
Infant Nutritional Physiological Phenomena
Maternal Behavior
lcsh:RJ1-570
Pediatrik
Juvenile idiopathic arthritis (JIA)
Nutrition
Rheumatic disease
Regular Article
Breast Feeding
Female
Adult
medicine.medical_specialty
Breast milk
03 medical and health sciences
Rheumatology
medicine
Humans
030203 arthritis & rheumatology
Sweden
business.industry
Case-control study
Infant
lcsh:Pediatrics
medicine.disease
Arthritis, Juvenile
Socioeconomic Factors
Case-Control Studies
Pediatrics, Perinatology and Child Health
Etiology
Physical therapy
lcsh:RC925-935
business
Subjects
Details
- Language :
- English
- ISSN :
- 15460096
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Pediatric Rheumatology Online Journal
- Accession number :
- edsair.doi.dedup.....769c9bd07109c6b89d6a04749800e794