Back to Search
Start Over
Macula Ganglion Cell Thickness Changes Display Location-Specific Variation Patterns in Intermediate Age-Related Macular Degeneration
- Source :
- Investigative Ophthalmology & Visual Science
- Publication Year :
- 2020
- Publisher :
- Association for Research in Vision and Ophthalmology (ARVO), 2020.
-
Abstract
- Purpose The purpose of this study was to examine changes in the ganglion cell layer (GCL) of individuals with intermediate age-related macular degeneration (AMD) using grid-wise analysis for macular optical coherence tomography (OCT) volume scans. We also aim to validate the use of age-correction functions for GCL thickness in diseased eyes. Methods OCT macular cube scans covering 30° × 25° were acquired using Spectralis spectral-domain OCT for 87 eyes with intermediate AMD, 77 age-matched normal eyes, and 254 non-age-matched normal eyes. The thickness of the ganglion cell layer (GCL) was defined after segmentation at 60 locations across an 8 × 8 grid centered on the fovea, where each grid location covered 0.74 mm2 (approximately 3° × 3°) within the macula. Each GCL location of normal eyes (n = 77) were assigned to a specific iso-ganglion cell density cluster in the macula, based on patterns of age-related GCL thickness loss. Analyses were then performed comparing AMD GCL grid-wise data against corresponding spatial clusters, and significant AMD GCL thickness changes were denoted as values outside the 95% distribution limits. Results Analysis of GCL thickness changes revealed significant differences between spatial clusters, with thinning toward the fovea, and thickening toward the peripheral macula. The direction of GCL thickness changes in AMD were associated more so with thickening than thinning in all analyses. Results were corroborated by the application of GCL thickness age-correction functions. Conclusions GCL thickness changed significantly and nonuniformly within the macula of intermediate AMD eyes. Further characterization of these changes is critical to improve diagnoses and monitoring of GCL-altering pathologies.
- Subjects :
- Male
Retinal Ganglion Cells
Aging
medicine.medical_specialty
Materials science
genetic structures
Retina
Macular Degeneration
03 medical and health sciences
0302 clinical medicine
Macula Lutea
Optical coherence tomography
Ophthalmology
Age related
medicine
Humans
age-related macular degeneration
Ganglion cell layer
Aged
Retrospective Studies
Aged, 80 and over
optical coherence tomography
medicine.diagnostic_test
Middle Aged
Macular degeneration
medicine.disease
eye diseases
Ganglion
medicine.anatomical_structure
Case-Control Studies
030221 ophthalmology & optometry
Spatial clustering
Macula densa
Female
sense organs
inner retinal thickness
Tomography, Optical Coherence
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15525783
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Investigative Opthalmology & Visual Science
- Accession number :
- edsair.doi.dedup.....7699ec65cc01c13deeaf0315b2cf90a7