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Effect of Thermoresponsive Poly(L-lactic acid)-poly(ethylene glycol) Gel Injection on Left Ventricular Remodeling in a Rat Myocardial Infarction Model
- Source :
- Tissue engineering and regenerative medicine. 14(5)
- Publication Year :
- 2017
-
Abstract
- Some gel types have been reported to prevent left ventricular (LV) remodeling in myocardial infarction (MI) animal models. In this study, we tested biodegradable thermoresponsive gels. Poly(L-lactic acid)–poly(ethylene glycol) (PLLA–PEG) and poly(D-lactic acid)–poly(ethylene glycol) (PDLA–PEG) were synthesized by the polycondensation of l- and D-lactic acids in the presence of PEG and succinic acid. Each of these block copolymers was used to prepare particles dispersed in an aqueous medium and mixed together to obtain a PLLA–PEG/PDLA–PEG suspension, which was found to show a sol-to-gel transition around the body temperature by the stereocomplex formation of enantiomeric PLLA and PDLA sequences. In the present study, the G′ of the PLLA–PEG/PDLA–PEG suspension in the rheological measurement remained as low as 1 Pa at 20 °C and increased 2 kPa at 37 °C. The sol–gel systems of PLLA–PEG/PDLA–PEG might be applicable to gel therapy. The effect of the PLLA–PEG/PDLA–PEG gel injection was compared with that of a calcium-crosslinked alginate gel and saline in a rat MI model. The percent fractional shortening improved in the PLLA–PEG/PDLA–PEG (20.8 ± 4.1%) and alginate gel (21.1 ± 4.8%) compared with the saline (14.2 ± 2.8%) with regard to the echocardiograph 4 weeks after the injection (p
- Subjects :
- Chromatography
Condensation polymer
medicine.medical_treatment
technology, industry, and agriculture
Biomedical Engineering
Medicine (miscellaneous)
macromolecular substances
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
medicine.disease
01 natural sciences
0104 chemical sciences
chemistry.chemical_compound
chemistry
Succinic acid
PEG ratio
Copolymer
medicine
Original Article
Enantiomer
0210 nano-technology
Ventricular remodeling
Ethylene glycol
Saline
Subjects
Details
- ISSN :
- 22125469
- Volume :
- 14
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Tissue engineering and regenerative medicine
- Accession number :
- edsair.doi.dedup.....7697cf87b18a58f86913f96e0e6af46c