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Childhood Fractures Do Not Predict Future Fractures: Results From the European Prospective Osteoporosis Study
- Source :
- Todd, C, Pye, S R, Tobias, J, Silman, A J, Reeve, J & O'Neill, T W 2009, ' Childhood fractures do not predict future fractures: Results from the European prospective osteoporosis study ', Journal of Bone and Mineral Research, vol. 24, no. 7, pp. 1314-1318 . https://doi.org/10.1359/jbmr.090220
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Childhood fractures are common. Their clinical relevance to osteoporosis and fractures in later life is unclear. The aim of this study was to determine the predictive risk of childhood fracture on the risk of fracture in later life. Men and women ≥50 yr of age were recruited from population registers for participation in the European Prospective Osteoporosis Study (EPOS). Subjects completed an interviewer administered questionnaire that included questions about previous fractures and the age at which the first of these fractures occurred. Lateral spine radiographs were performed to ascertain prevalent vertebral deformities. Subjects were followed prospectively by postal questionnaire to determine the occurrence of clinical fractures. A subsample of subjects had BMD measurements performed. Cox proportional hazards model was used to determine the predictive risk of childhood fracture between the ages of 8 and 18 yr on the risk of future limb fracture and logistic regression was used to determine the association between reported childhood fractures and prevalent vertebral deformity. A total of 6451 men (mean age, 63.8 yr) and 6936 women (mean age, 63.1 yr) were included in the analysis. Mean follow-up time was 3 yr. Of these, 574 (8.9%) men and 313 (4.5%) women reported a first fracture (any site) between the ages of 8 and 18 yr. A recalled history of any childhood fracture or forearm fracture was not associated with an increased risk of future limb fracture or prevalent vertebral deformity in either men or women. Among the 4807 subjects who had DXA measurements, there was no difference in bone mass among those subjects who had reported a childhood fracture and those who did not. Our data suggest that self-reported previous childhood fracture is not associated with an increased risk of future fracture in men or women. © 2009 American Society for Bone and Mineral Research.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Adolescent
Epidemiology
Endocrinology, Diabetes and Metabolism
Osteoporosis
Population
Fractures, Bone
Incident limb fracture
Predictive Value of Tests
Risk Factors
medicine
Humans
Orthopedics and Sports Medicine
Prospective Studies
Registries
Age of Onset
Prospective study
Child
education
Prospective cohort study
Aged
education.field_of_study
business.industry
Proportional hazards model
Limb fracture
Middle Aged
Prevalent vertebral fracture
medicine.disease
Europe
Predictive value of tests
Physical therapy
Female
Childhood fracture
Age of onset
business
Subjects
Details
- ISSN :
- 08840431
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Bone and Mineral Research
- Accession number :
- edsair.doi.dedup.....76919d3380b108b1129818a008564e8d