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Protocatechuic acid protects against hepatorenal toxicities in rats exposed to Furan
- Source :
- Drug and Chemical Toxicology. 45:1840-1850
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Furan formed in processed food is hepatotoxic and likely carcinogenic in humans. We investigated protocatechuic acid (PCA) protective role in rats' hepatorenal function treated with furan. Rats were grouped and treated as follows: Control, PCA (50 mg/kg), furan alone (8 mg/kg), furan + PCA1 (25 + 8 mg/kg), and furan + PCA2 (50 + 8 mg/kg). Upon sacrifice, evaluation of hepatorenal function, oxidative stress status, reactive oxygen and nitrogen species (RONS), lipid peroxidation (LPO), myeloperoxidase (MPO) activity, among nitric oxide (NO) levels were performed. Cytokine levels (IL-10, IL-1ß, TNF-alpha), Caspase 3 and 9 activities, and histopathological examination were also assessed. We found that the final body and relative liver weights changed significantly
- Subjects :
- Health, Toxicology and Mutagenesis
010501 environmental sciences
Pharmacology
Kidney
Toxicology
01 natural sciences
Antioxidants
Protocatechuic acid
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Furan
Hydroxybenzoates
Animals
Furans
Carcinogen
0105 earth and related environmental sciences
Chemical Health and Safety
Tumor Necrosis Factor-alpha
Chemistry
Public Health, Environmental and Occupational Health
General Medicine
Reactive Nitrogen Species
Interleukin-10
Rats
Oxidative Stress
Liver
Phytochemical
Reactive Oxygen Species
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15256014 and 01480545
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Drug and Chemical Toxicology
- Accession number :
- edsair.doi.dedup.....768c169640f138742fe1c284a4a30097