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Methodological decisions influence the identification of potential core outcomes in studies related to pre-eclampsia: an analysis informing the development of recommendations for future core outcome set developers
- Source :
- BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
- Publication Year :
- 2019
-
Abstract
- © 2019 Royal College of Obstetricians and Gynaecologists Objective: To quantify the effect of different methodological decisions on the identification of potential core outcomes to inform the development of recommendations for future core coutcome set developers. Design: Mixed methods study. Setting: A core outcome set for pre-eclampsia was used as an exemplar. Sample: A long list of potential core outcomes was developed by undertaking a systematic review of pre-eclampsia trials and performing a thematic analysis of in-depth patient interviews. Methods: Specific methods used to generate long lists of potential core outcomes were evaluated. Results: Different methodological decisions had a substantial impact on the identification of potential core outcomes. Extracting outcomes from published pre-eclampsia trials was an effective way of identifying 48 maternal, eight fetal, 25 neonatal outcomes, and eight patient-reported outcomes. Limiting the extraction of outcomes to primary outcomes or outcomes commonly reported in pre-eclampsia trials reduced the number and diversity of potential core outcomes identified. Thematic analysis of in-depth patient interviews ensured an additional five patient reported outcomes and six outcomes related to future child health were identified. Conclusions: Future core outcome set developers should use quantitative and qualitative methods when developing a long list of potential core outcomes. Tweetable abstract: @OfficialNIHR research published in @BJOGtweets informs new recommendations for future @coreoutcomes developers.
- Subjects :
- Medical education
030219 obstetrics & reproductive medicine
business.industry
Obstetrics and Gynecology
Sample (statistics)
Outcome (game theory)
Child health
Decision Support Techniques
03 medical and health sciences
Identification (information)
Core (game theory)
0302 clinical medicine
Pre-Eclampsia
Pregnancy
Prenatal Diagnosis
Outcome Assessment, Health Care
Humans
Medicine
Female
Thematic analysis
business
Set (psychology)
Qualitative research
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
- Accession number :
- edsair.doi.dedup.....76836d6e914e4fa2f28d897404015dac