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The molecular basis of pneumococcal infection: a hypothesis
- Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 21
- Publication Year :
- 1995
-
Abstract
- New insight has been gained into the mechanisms underlying the tissue tropism and inflammation of pneumococcal infection. Virulence has been linked to a transparent colonial morphology. Adherence has been characterized at the molecular level, and the importance of receptors arising upon activation of eukaryotic cells in promoting the progression to disease has been established. The contribution of peptidoglycan and teichoic acid to the generation of inflammation has suggested the need to couple anti-inflammatory therapy with antibiotic treatment in order to improve the outcome of invasive disease. Elucidation of the pathogenesis of pneumococcal infection, including the identification of virulence determinants by recently developed genetic strategies, can provide a paradigm for new mechanisms that are active in gram-positive bacterial infections and that are clearly distinct from the familiar pathways triggered by endotoxin.
- Subjects :
- Microbiology (medical)
Molecular Sequence Data
Virulence
Inflammation
Receptors, Cell Surface
Disease
Platelet Membrane Glycoproteins
Biology
medicine.disease_cause
Disaccharides
Models, Biological
Bacterial Adhesion
Pneumococcal Infections
Microbiology
Receptors, G-Protein-Coupled
Pathogenesis
Bacterial Proteins
Cell Movement
Cell Wall
Streptococcus pneumoniae
medicine
Pneumonia, Bacterial
Humans
Tropism
Galactose
medicine.disease
Pneumococcal infections
Otitis Media
Infectious Diseases
Carbohydrate Sequence
Immunology
Tissue tropism
Endothelium, Vascular
medicine.symptom
Subjects
Details
- ISSN :
- 10584838
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Accession number :
- edsair.doi.dedup.....767e7bd2703ec52ecfa4aba75cd3a7f0