Back to Search
Start Over
Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption
- Source :
- Neuroscience letters. 406(1-2)
- Publication Year :
- 2006
-
Abstract
- The hippocampal formation has been shown to be particularly vulnerable to the neurotoxic effects of chronic ethanol consumption. It was hypothesized that this damage was due to the disruption of the expression of neurotrophic factors and certain other proteins within the hippocampus. By using real-time reverse transcription-polymerase chain reaction (RT-PCR) techniques, this study aimed to determine whether chronic ethanol consumption could alter the mRNA expression level of brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), and oligodendrocyte myelin glycoprotein (OMgp) in the hippocampus. Wistar male rats received an unrestricted access to a liquid diet containing 5% (v/v) ethanol as the sole source of fluid from 10 to 29 weeks of age. Control rats had unlimited access to a liquid diet containing an isocaloric amount of sucrose. We found that chronic ethanol consumption did not cause significant changes in the levels of mRNA for BDNF and GDNF. However, OMgp mRNA showed a significant deficit in ethanol-treated animals. It is suggested that this deficit may be related to the demyelination that is commonly observed in human alcoholics and that this may contribute to the functional and cognitive deficits.
- Subjects :
- Male
medicine.medical_specialty
Liquid diet
Down-Regulation
Hippocampal formation
GPI-Linked Proteins
Hippocampus
Nerve Fibers, Myelinated
Myelin
Alcohol-Induced Disorders, Nervous System
Neurotrophic factors
Internal medicine
medicine
Glial cell line-derived neurotrophic factor
Animals
Glial Cell Line-Derived Neurotrophic Factor
RNA, Messenger
Rats, Wistar
Brain-derived neurotrophic factor
biology
Ethanol
Chemistry
General Neuroscience
Brain-Derived Neurotrophic Factor
Central Nervous System Depressants
Organ Size
Oligodendrocyte
Rats
Disease Models, Animal
Myelin-Associated Glycoprotein
Endocrinology
medicine.anatomical_structure
nervous system
Chronic Disease
biology.protein
Neuroglia
Myelin-Oligodendrocyte Glycoprotein
Atrophy
Myelin Proteins
Demyelinating Diseases
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 406
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....766ded3fb180bd0f29718b6dae651071