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A model of respiratory syncytial virus (RSV) infection of infants in newborn lambs
- Source :
- Cell and Tissue Research
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Many animal models have been established for respiratory syncytial virus (RSV) infection of infants with the purpose of studying the pathogenesis, immunological response, and pharmaceutical testing and the objective of finding novel therapies and preventive measures. This review centers on a neonatal lamb model of RSV infection that has similarities to RSV infection of infants. It includes a comprehensive description of anatomical and immunological similarities between ovine and human lungs along with comparison of pulmonary changes and immune responses with RSV infection. These features make the newborn lamb an effective model for investigating key aspects of RSV infection in infants. The importance of RSV lamb model application in preclinical therapeutic trials and current updates on new studies with the RSV-infected neonatal lamb are also highlighted.
- Subjects :
- 0301 basic medicine
Histology
viruses
Respiratory Syncytial Virus Infections
Review
Respiratory syncytial virus
Antiviral therapy
medicine.disease_cause
Neonatal lamb model
Virus
Pathology and Forensic Medicine
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Immune system
Animals
Humans
Medicine
Animal model
Respiratory system
Newborn lamb
business.industry
virus diseases
Cell Biology
respiratory system
Therapeutic trial
Disease Models, Animal
030104 developmental biology
Respiratory syncytial virus (RSV)
Animals, Newborn
Model application
Immunology
business
Infants
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14320878 and 0302766X
- Volume :
- 380
- Database :
- OpenAIRE
- Journal :
- Cell and Tissue Research
- Accession number :
- edsair.doi.dedup.....76604c37e29eedc2ce4175273e883bd7