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Influenza vaccination following liver transplantation in children
Influenza vaccination following liver transplantation in children
- Source :
- Liver Transplantation and Surgery. 2:431-437
- Publication Year :
- 1996
- Publisher :
- Wiley, 1996.
-
Abstract
- Our objective was to determine the immunologic response to two influenza vaccine doses in 39 children who had undergone liver transplantation. Patients received two doses of trivalent inactivated influenza vaccine 4 weeks apart. Sera were collected 4 weeks after each dose and analyzed by a hemagglutination inhibition assay (HAI) for evidence of antibody response to the antigens A/Taiwan/1/86 (H1N1), A/Beijing/32/92 (H3N2), and B/Panama/45/95. Patients with HAI titers of 1:40 or greater were considered to have protective titers. Twenty-six (67%) patients showed a 1:40 or greater titer response to A/Beijing/32/92 1 month after the first vaccination. Only two additional patients were found to have similar titers after the second dose. A higher proportion of patients with protective titers were on smaller amounts of prednisone for body weight or alternate day low dose (< 10 mg/day) prednisone compared to patients on daily low dose or daily high dose prednisone. Patients with protective titers were significantly older (9.0 +/- 2.8 years) than those without protective titers (4.2 +/- 3.4 years, p = .002) following the first inoculation of the A/Beijing/32/92 vaccine component. Similar results were found for the second vaccination and with the H1N1 antigen. Cyclosporine level, gender, and body mass index were not associated with any outcome measures. We conclude that most liver transplant recipients had a protective antibody titer after a single influenza inoculation, but little further advantage was gained after an additional dose. Vaccination of household contacts of younger patients and those patients on daily prednisone or patient chemoprophylaxis may offer greater benefit in prevention of influenza in liver transplant recipients than multiple vaccine doses with current vaccine preparations.
- Subjects :
- Graft Rejection
Male
medicine.medical_specialty
Adolescent
Influenza vaccine
medicine.medical_treatment
Liver transplantation
Gastroenterology
Statistics, Nonparametric
Antigen
Prednisone
Internal medicine
Influenza, Human
medicine
Humans
Vaccines, Combined
Child
Immunization Schedule
Hemagglutination assay
Dose-Response Relationship, Drug
Hepatology
business.industry
Age Factors
Infant
Hemagglutination Tests
Liver Transplantation
Vaccination
Titer
Influenza Vaccines
Child, Preschool
Antibody Formation
Chemoprophylaxis
Immunology
Female
Surgery
business
Immunosuppressive Agents
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 10743022
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Liver Transplantation and Surgery
- Accession number :
- edsair.doi.dedup.....7658fb255ab0416749c6db5b430fb297
- Full Text :
- https://doi.org/10.1002/lt.500020605