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Analysis of Peripheral T-cell Lymphoma Diagnostic Workup in the United States
- Source :
- Clinical Lymphoma Myeloma and Leukemia. 17:193-200
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background With increased understanding of the unique entities, subtype-specific approaches for peripheral T-cell lymphoma (PTCL) are emerging, and more precise diagnoses are becoming increasingly important. Patients and Methods We analyzed the approach to the histopathologic diagnosis of PTCL using data from the comprehensive oncology measures of peripheral T-cell lymphoma (COMPLETE) study. The COMPLETE trial is a large prospective cohort study of patients with newly diagnosed PTCL in the United States. Results A total of 499 patients were enrolled from 40 academic and 15 community-based centers. Baseline assessment forms were collected for 493 patients, of which 435 (88%) were available for analysis. The most common diagnoses were PTCL, not otherwise specified (PTCL-NOS), anaplastic large cell lymphoma, and angioimmunoblastic T-cell lymphoma (AITL). A mean of 10 markers (range, 0-21) was assessed per patient. CD30 was assessed frequently but not uniformly in cases that were not anaplastic large cell lymphoma. Only 17% of PTCL-NOS cases were assessed for PD1. CXCL13 was a relatively sensitive marker in AITL, expressed in 84% of tested cases; however, only 3% of PTCL-NOS cases were tested. T follicular helper cell marker assessment differed between academic and community practices, with PD1 more often evaluated by academic centers in cases of AITL (62% vs. 12%; P = .01). Conclusion The diagnostic workup for PTCL in the United States varies widely and often lacks important phenotypic information to fully characterize the lymphoma. Gaps in testing of selected markers should be filled, given the impending revision to the World Health Organization classification. The accuracy of diagnosis will become increasingly important as we enter the era of targeted treatment for PTCL.
- Subjects :
- Biomarkers
Diagnosis
Histopathologic type
Practice
Prospective studies
Hematology
Oncology
Cancer Research
Adult
Male
medicine.medical_specialty
Pathology
Adolescent
CD30
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
Biomarkers, Tumor
medicine
Humans
Prospective Studies
Medical diagnosis
Prospective cohort study
Anaplastic large-cell lymphoma
Aged
Aged, 80 and over
business.industry
Not Otherwise Specified
Lymphoma, T-Cell, Peripheral
Middle Aged
medicine.disease
Chemokine CXCL13
United States
Peripheral T-cell lymphoma
Lymphoma
Immunoblastic Lymphadenopathy
030220 oncology & carcinogenesis
Lymphoma, Large-Cell, Anaplastic
Female
business
030215 immunology
Subjects
Details
- ISSN :
- 21522650
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Clinical Lymphoma Myeloma and Leukemia
- Accession number :
- edsair.doi.dedup.....764f74a273234b0d460de1bca4234b8b