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Plastic Heterogeneity of Innate Lymphoid Cells in Cancer
- Source :
- Trends in Cancer. 3:326-335
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Innate lymphoid cells (ILCs) fulfill important protective and reparative functions, and have thus been implicated in the maintenance of tissue homeostasis. Dysregulation of their activation is associated with several autoimmune and inflammatory diseases. The current literature on the role of ILCs in cancer is limited and our knowledge is therefore incomplete. Indeed, ILCs have been separately associated with tumor-promoting as well as tumor-suppressing activities, raising the need to understand the mechanisms by which these cells regulate tumor growth and progression toward a rational design of therapeutic approaches. We focus here on the heterogeneity of ILCs and discuss currently known mechanisms of their plasticity.
- Subjects :
- 0301 basic medicine
Cancer Research
Inflammation
Biology
03 medical and health sciences
0302 clinical medicine
Immunity
Neoplasms
medicine
Humans
Tumor growth
Lymphocytes
skin and connective tissue diseases
Tumor stroma
Tissue homeostasis
Tumor microenvironment
Innate lymphoid cell
Cancer
medicine.disease
Immunity, Innate
body regions
030104 developmental biology
Oncology
Immunology
medicine.symptom
Neuroscience
030215 immunology
Subjects
Details
- ISSN :
- 24058033
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Trends in Cancer
- Accession number :
- edsair.doi.dedup.....764c0fe80de704163eab3bac00b9920a