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Onset Age is Associated with Outcome of Radioiodine Therapy in Graves' Disease
- Source :
- Endocrine Journal. 51:127-132
- Publication Year :
- 2004
- Publisher :
- Japan Endocrine Society, 2004.
-
Abstract
- Controversy remains regarding the optimal dose calculation with radioiodine therapy for patients with Graves' disease. Here, we focused our analysis on data concerning the patient's pretreatment background, an empirically set dose of radioiodine and the post-treatment thyroid function, and investigated those factors that affected the outcome. The subjects consisted of 38 patients diagnosed as having Graves' disease. All patients were hospitalized to undertake radioiodine therapy between 1989 and 1998 at our hospital. At the follow-up periods of 6-, 12-, and 36-months after therapy, we divided the patients into two groups: one group those who had hypothyroid function, and the other those who had normal or hyperthyroid function. At 6- and 12-months, 50% of the patients belonged to the hypothyroid function group, whereas at 36-months, 55% of them had hypothyroid function. Logistic regression analysis, with the objective variable being the post-treatment hypothyroidism after 12 months, revealed that the significant factor was the onset age. We suggested that the age at onset should be considered in patients with Graves' disease to determine the optional radioiodine dose for the therapy.
- Subjects :
- Adult
Male
endocrine system
Pediatrics
medicine.medical_specialty
Time Factors
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Graves' disease
Thyroid Gland
Disease
Logistic regression
Iodine Radioisotopes
Endocrinology
medicine
Humans
In patient
Age of Onset
business.industry
Thyroid
Function group
Dose-Response Relationship, Radiation
Radioiodine therapy
Middle Aged
Prognosis
medicine.disease
Graves Disease
Logistic Models
Treatment Outcome
medicine.anatomical_structure
Female
Thyroid function
Nuclear medicine
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 13484540 and 09188959
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Endocrine Journal
- Accession number :
- edsair.doi.dedup.....7635c6d6de7273a01af8d6ee4c3ba7c0