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Six new alkaloids from Melodinus henryi
- Source :
- Fitoterapia. 100:133-138
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- A total of six new alkaloids, melodinhenines A-F (1-6), were isolated from Melodinus henryi. Melodinhenines A and B are new eburnan-vindolinine-type bisindole alkaloids and melodinhenines C-F are new quinolinic melodinus alkaloids. Their structures were elucidated through extensive spectroscopic methods including 2D NMR and HRESIMS analyses. The absolute configuration of 1 and 2 was determined using ECD exciton chirality method. To the best of our knowledge, this is the first report on the determination of the absolute configuration of eburnan-vindolinine-type bisindole alkaloid using this method.
- Subjects :
- Pharmacology
Molecular Structure
Plant Stems
biology
Stereochemistry
Chemistry
Alkaloid
Absolute configuration
General Medicine
biology.organism_classification
Indole Alkaloids
Apocynaceae
Melodinus
Alkaloids
Drug Discovery
Organic chemistry
Chirality (chemistry)
Two-dimensional nuclear magnetic resonance spectroscopy
Subjects
Details
- ISSN :
- 0367326X
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....76317d80b281a2a634f8e54f19435a4b