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Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension
- Source :
- LOCUS Repositório Institucional da UFV, Universidade Federal de Viçosa (UFV), instacron:UFV
- Publication Year :
- 2017
-
Abstract
- Aim Investigate to what extent low-intensity swim training for six weeks counterbalances the adverse remodeling due to the advance of pathological hypertrophy in the left ventricle (LV) structural and mechanical properties in the early compensated phase of hypertension in male SHR. Main methods Four-month-old male SHR and Wistar rats were randomly divided into Sed (sedentary) and Ex (exercised) groups. The exercised rats were submitted to a swimming protocol (1 h/day, 5 times/week, no additional load) for six weeks. LV tissue and isolated myocytes were used to assess structural and mechanical properties. Myocytes were stimulted at frequencies (F) of 1 and 3 Hz at 37 °C. Key findings Exercised SHR showed improvement in cardiovascular parameters compared to sedentary SHR (mean arterial pressure: 13.22%; resting HR: 14.28.%). About structural and mechanical properties, swim training induced a decrease in LV myocyte thickness (10.85%), number of inflammatory cells (21.24%); collagen type III (74.23%) and type I (85.6%) fiber areas; amplitude of single myocyte shortening (47% to F1 and 28.46% to F3), timecourses of shortening (16.5% to F1 and 7.55% to F3) and relaxation (15.31% to F3) compared to sedentary SHR. Significance Six weeks of swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension in male SHR.
- Subjects :
- 0301 basic medicine
Male
Mean arterial pressure
medicine.medical_specialty
Heart Ventricles
Muscle Relaxation
Isolated myocytes
Blood Pressure
030204 cardiovascular system & hematology
General Biochemistry, Genetics and Molecular Biology
Collagen Type I
Muscle hypertrophy
03 medical and health sciences
0302 clinical medicine
Swim training
Heart Rate
Internal medicine
Physical Conditioning, Animal
medicine
Myocyte
Animals
Myocytes, Cardiac
General Pharmacology, Toxicology and Pharmaceutics
Physical Therapy Modalities
Swimming
computer.programming_language
Cardiac remodeling
Cardiomyocytes
Ventricular Remodeling
sed
business.industry
General Medicine
Hypertrophy
Electric Stimulation
Rats
030104 developmental biology
medicine.anatomical_structure
Collagen Type III
Ventricle
Spontaneously hypertensive rats
Hypertension
Cardiology
business
computer
Muscle Contraction
Subjects
Details
- ISSN :
- 18790631
- Volume :
- 187
- Database :
- OpenAIRE
- Journal :
- Life sciences
- Accession number :
- edsair.doi.dedup.....762fa2c736ef6e9302e8a61e3fe622aa