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Development and regulation of RORγt + innate lymphoid cells

Authors :: Sascha Cording
Gérard Eberl
Jasna Medvedovic
Marie Cherrier
Développement des Tissus Lymphoïdes
Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)
Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151))
Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
This work has been supported by grants from the Agence Nationale de la Recherche, the Fond de la Recherche Médicale, the Institut Pasteur and a Marie Curie intra-European fellowship to S.C.
Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS )
Institut Necker Enfants-Malades (INEM) ( INEM - UM 111 (UMR 8253 / U1151) )
Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS )
Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris]
Source :: FEBS Letters, FEBS Letters, Wiley, 2014, 588 (22), pp.4176-4181. ⟨10.1016/j.febslet.2014.03.034⟩, FEBS Letters, 2014, 588 (22), pp.4176-4181. ⟨10.1016/j.febslet.2014.03.034⟩, FEBS Letters, Wiley, 2014, 588 (22), pp.4176-4181. 〈10.1016/j.febslet.2014.03.034〉
Publication Year :: 2014
Publisher :: HAL CCSD, 2014.
Abstract: International audience; RORγt(+) innate lymphoid cells (ILCs), or ILC3, play a fundamental role in the development of lymphoid tissues, as well as in homeostasis and defence of mucosal tissues. These cells produce IL-22, IL-17A and LTα1β2, key cytokines for the activation of epithelial defences and the recruitment of polymorphonuclear phagocytes. In the absence of ILC3, the early defence to infection and resistance to injury are compromised. Given the importance of ILC3 in mucosal immunity, significant efforts are made to discover their multiple functions and decipher their mode of action and regulation.

Details

Language :: English
ISSN :: 00145793 and 18733468
Database :: OpenAIRE
Journal :: FEBS Letters, FEBS Letters, Wiley, 2014, 588 (22), pp.4176-4181. ⟨10.1016/j.febslet.2014.03.034⟩, FEBS Letters, 2014, 588 (22), pp.4176-4181. ⟨10.1016/j.febslet.2014.03.034⟩, FEBS Letters, Wiley, 2014, 588 (22), pp.4176-4181. 〈10.1016/j.febslet.2014.03.034〉
Accession number :: edsair.doi.dedup.....76284cf814285994cf584faa480aa426
Full Text :: https://doi.org/10.1016/j.febslet.2014.03.034⟩