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Thermodynamic Approach to Phase Coexistence in Ternary Phospholipi-Cholesterol Mixtures

Authors :
Fabrice Thalmann
Carlos M. Marques
Jean Wolff
Institut Charles Sadron (ICS)
Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique
Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE)
Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Source :
Physical Review Letters, Physical Review Letters, American Physical Society, 2011, 106, pp.128104. ⟨10.1103/PhysRevLett.106.128104⟩
Publication Year :
2011

Abstract

We introduce a simple and predictive model for determining the phase stability of ternary phospholipid-cholesterol mixtures. Assuming that competition between the liquid and gel order of the phospholipids is the main driving force behind lipid segregation, we derive a Gibbs free energy of mixing, based on the thermodynamic properties of the lipids main transition. A numerical approach was devised that enables the fast and efficient determination of the ternary diagrams associated with our Gibbs free energy. The computed phase coexistence diagram of DOPC/DPPC/cholesterol reproduces well-known features for this system at $10\text{ }\ifmmode^\circ\else\textdegree\fi{}\mathrm{C}$, as well as its evolution with temperature.

Details

Language :
English
ISSN :
00319007 and 10797114
Database :
OpenAIRE
Journal :
Physical Review Letters, Physical Review Letters, American Physical Society, 2011, 106, pp.128104. ⟨10.1103/PhysRevLett.106.128104⟩
Accession number :
edsair.doi.dedup.....7618d804759ab3eae1424b8aacd27d84