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Thermodynamic Approach to Phase Coexistence in Ternary Phospholipi-Cholesterol Mixtures
- Source :
- Physical Review Letters, Physical Review Letters, American Physical Society, 2011, 106, pp.128104. ⟨10.1103/PhysRevLett.106.128104⟩
- Publication Year :
- 2011
-
Abstract
- We introduce a simple and predictive model for determining the phase stability of ternary phospholipid-cholesterol mixtures. Assuming that competition between the liquid and gel order of the phospholipids is the main driving force behind lipid segregation, we derive a Gibbs free energy of mixing, based on the thermodynamic properties of the lipids main transition. A numerical approach was devised that enables the fast and efficient determination of the ternary diagrams associated with our Gibbs free energy. The computed phase coexistence diagram of DOPC/DPPC/cholesterol reproduces well-known features for this system at $10\text{ }\ifmmode^\circ\else\textdegree\fi{}\mathrm{C}$, as well as its evolution with temperature.
- Subjects :
- Models, Molecular
Materials science
PACS 87.16.dt, 64.75.-b, 87.14.Cc
FOS: Physical sciences
General Physics and Astronomy
Thermodynamics
Ternary plot
02 engineering and technology
ternary
Entropy of mixing
Condensed Matter - Soft Condensed Matter
010402 general chemistry
01 natural sciences
Phase Transition
lipids
Quantitative Biology::Subcellular Processes
symbols.namesake
Phase (matter)
Lipid bilayer phase behavior
phase
theoretical
Phospholipids
Physics::Biological Physics
Diagram
Temperature
coexistence
technology, industry, and agriculture
Order (ring theory)
transition
cholesterol
021001 nanoscience & nanotechnology
0104 chemical sciences
Gibbs free energy
Condensed Matter::Soft Condensed Matter
symbols
Soft Condensed Matter (cond-mat.soft)
lipids (amino acids, peptides, and proteins)
0210 nano-technology
Ternary operation
[PHYS.COND.CM-SCM]Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft]
Subjects
Details
- Language :
- English
- ISSN :
- 00319007 and 10797114
- Database :
- OpenAIRE
- Journal :
- Physical Review Letters, Physical Review Letters, American Physical Society, 2011, 106, pp.128104. ⟨10.1103/PhysRevLett.106.128104⟩
- Accession number :
- edsair.doi.dedup.....7618d804759ab3eae1424b8aacd27d84