Back to Search
Start Over
A preclinical randomized controlled study of ischemia treated with Ginkgo biloba extracts: Are complex components beneficial for treating acute stroke?
A preclinical randomized controlled study of ischemia treated with Ginkgo biloba extracts: Are complex components beneficial for treating acute stroke?
- Source :
- Current research in translational medicine. 68(4)
- Publication Year :
- 2020
-
Abstract
- The rigorous design of preclinical experimental studies of candidate neuroprotectants for the treatment of acute ischemic stroke is crucial for the success of subsequent randomized clinical trials. The efficacy of Ginkgo biloba extracts (GBEs) in complex mixtures for the treatment of acute ischemic stroke remains unclear. In this preclinical randomized controlled trail (pRCT), the effects of a novel (n)GBE containing pinitol versus traditional (t)GBE without pinitol were evaluated on the mouse models of acute transient and permanent stroke, separately. The sample size, an important aspect of study design, was calculated based on our experimental data. Mice with ischemia that were induced by transient middle cerebral artery occlusion (tMCAO) or permanent distal middle cerebral artery occlusion (pdMCAO), were treated with vehicle, nGBE, tGBE, or pinitol alone by tail-vein injection. Our results showed that nGBE significantly reduced infarct size in mice with tMCAO compared with vehicle-treated control mice. Both nGBE and tGBE significantly reduced infarct size in mice with pdMCAO compared with the vehicle-treated controls. None of the three treatments rescued weight loss or prevented the neurological deficits in either the tMCAO- or pdMCAO-model mice. These findings suggest that nGBE, which includes all of the components of tGBE and pinitol, is neuroprotective in two ischemic stroke models. Additional studies of complex GBE mixtures for stroke treatment compared to single component medications are undergoing evaluation.
- Subjects :
- 0301 basic medicine
Ischemia
Pharmacology
Neuroprotection
General Biochemistry, Genetics and Molecular Biology
law.invention
Brain Ischemia
03 medical and health sciences
chemistry.chemical_compound
Mice
Random Allocation
0302 clinical medicine
Randomized controlled trial
Weight loss
law
medicine
Animals
Stroke
Acute stroke
biology
Pinitol
Ginkgo biloba
business.industry
Plant Extracts
General Medicine
medicine.disease
biology.organism_classification
030104 developmental biology
Neuroprotective Agents
chemistry
030220 oncology & carcinogenesis
medicine.symptom
business
Subjects
Details
- ISSN :
- 24523186
- Volume :
- 68
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Current research in translational medicine
- Accession number :
- edsair.doi.dedup.....75fa251d10cdd1a8ecad758f281149ed