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CD2: a functional adhesion molecule on murine B cells, involved in interleukin-4-induced aggregation
- Source :
- European Journal of Immunology. 23:888-892
- Publication Year :
- 1993
- Publisher :
- Wiley, 1993.
-
Abstract
- The murine equivalent to CD2, previously known as a T cell marker, is expressed on mouse B cells. The monoclonal anti-CD2 antibody 12-15 was found to induce B cell homotypic adhesion. When treated with F(ab')2 fragments of 12-15, purified, resting B cells aggregate within 2 h of incubation and the response is optimal after 20 h. Anti-CD2-induced aggregation is a dose-related active process, dependent on temperature, metabolic energy and divalent cations. Aggregation is inhibited by two different Fab monomers of anti-CD2, implying that it is the CD2 molecule itself that functions as an adhesion molecule. We also report that interleukin 4-induced B cell homotypic adhesion involves CD2-mediated cell binding, since the antibodies specific for mouse, CD2, inhibited interleukin-4-induced cell aggregation.
- Subjects :
- Antigens, Differentiation, T-Lymphocyte
Cations, Divalent
Immunology
CD2 Antigens
Mice, Inbred Strains
Biology
CD2 molecule
Mice
Cell–cell interaction
Cell Adhesion
medicine
Animals
Immunology and Allergy
Receptors, Immunologic
Interleukin 4
B cell
Cell Aggregation
B-Lymphocytes
Receptors, Leukocyte-Adhesion
Cell adhesion molecule
Temperature
Interleukin
Adhesion
Cell aggregation
Cell biology
medicine.anatomical_structure
Biochemistry
Interleukin-4
Energy Metabolism
Cell Adhesion Molecules
Subjects
Details
- ISSN :
- 00142980
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- European Journal of Immunology
- Accession number :
- edsair.doi.dedup.....75f72c54b95befca1555d341bebb6a8c