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The effects of vagal nerve stimulation in focal cerebral ischemia and reperfusion model
- Source :
- Turkish Neurosurgery.
- Publication Year :
- 2013
- Publisher :
- Turkish Neurosurgical Society, 2013.
-
Abstract
- AIM: This study aimed to investigate the effects of VNS in transient middle cerebral artery occlusion and reperfusion (MCAO/R) rat model of ischemia based on behavioral, morphological, and molecular approaches. MATERIAL and METHODS: Wistar albino rats were divided into 3 groups: ischemia-reperfusion (I/R), I/R+VNS, and sham (for I/R). Each group was further divided into two subgroups for the assessment of neurological deficits and infarct area, or biochemical parameters related to oxidative stress. RESULTS: The infarct area and neurological scores were significantly lower in I/R+VNS group compared with the I/R group. MDA levels were significantly higher in I/R group compared to control and I/R+VNS groups in the cortical and subcortical specimens. There were also between-group differences in terms of GSH levels. GSH levels were higher in sham group compared with and I/R and I/R+VNS groups in cortical specimens whereas these levels for lower in I/R group compared to control and I/R+VNS groups in the subcortical specimens. SOD activity was higher in control group compared to I/R and I/R+VNS groups both in the cortical and subcortical specimens. There was no difference between I/R and I/R+VNS groups in neither cortical nor subcortical specimens. CONCLUSION:The neuroprotective and antioxidant properties of VNS suggest its efficacy as a potential anti-ischemic treatment.
- Subjects :
- Male
medicine.medical_specialty
Vagus Nerve Stimulation
Vagal nerve
Rat model
Ischemia
Tetrazolium Salts
Stimulation
medicine.disease_cause
Neuroprotection
Brain Ischemia
chemistry.chemical_compound
Malondialdehyde
Internal medicine
medicine
Animals
Middle cerebral artery occlusion
Rats, Wistar
Coloring Agents
Behavior, Animal
Superoxide Dismutase
business.industry
Infarction, Middle Cerebral Artery
Cerebral Infarction
Glutathione
medicine.disease
Electrodes, Implanted
Rats
Oxidative Stress
Endocrinology
chemistry
Reperfusion Injury
Anesthesia
Surgery
Neurology (clinical)
business
Oxidative stress
Subjects
Details
- ISSN :
- 10195149
- Database :
- OpenAIRE
- Journal :
- Turkish Neurosurgery
- Accession number :
- edsair.doi.dedup.....75f6f5b4b191cd92813f25b018b8b9bf