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CEACAM1 is overexpressed in oral tumors and related to tumorigenesis
- Source :
- Medical molecular morphology. 50(1)
- Publication Year :
- 2016
-
Abstract
- Carcinoembryonic antigen-related adhesion molecule 1 (CEACAM1) is a type 1 transmembrane glycoprotein belonging to the CEA family, which has been known to exist as either soluble forms in body fluids or membrane-bound forms on the cell surface. Aberrant CEACAM1 expression is associated with tumorigenesis and has been reported in a variety of human tumors, especially malignancies. The aim of this study is to determine the expression of CEACAM1 in oral tumors, trying to study CEACAM1 different expressions as a function of histotype. CEACAM1 expression was observed by immunohistochemistry (IHC) with mouse anti-human antibody for CEACAM1. IHC was performed using avidin-biotin-diaminobenzidine staining. The results were expressed as average score ± SD (0 = negative/8 = highest) for each histotype. Oral tumors expressed more CEACAM1 than normal tissues including squamous and salivary epithelia (P
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Carcinogenesis
Cell
Normal tissue
Biology
Adenocarcinoma
medicine.disease_cause
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Antigens, CD
medicine
Humans
Molecular Biology
Mouth
Poorly differentiated
General Medicine
Staining
030104 developmental biology
medicine.anatomical_structure
Cytoplasm
030220 oncology & carcinogenesis
Cancer research
biology.protein
Carcinoma, Squamous Cell
Immunohistochemistry
Mouth Neoplasms
Antibody
Cell Adhesion Molecules
Subjects
Details
- ISSN :
- 18601499
- Volume :
- 50
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Medical molecular morphology
- Accession number :
- edsair.doi.dedup.....75f07061695aedd2bea3f55eb5c25f16