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Second Generation 2-Aminoimidazole Based Advanced Glycation End Product Inhibitors and Breakers
- Publication Year :
- 2015
-
Abstract
- The formation of advanced glycation end-products (AGE) as a result of the action of reducing sugars on host macromolecules plays a role in increased morbidity of diabetic patients. There are currently no clinically available therapeutics for the prevention or eradication of AGEs. Following our previous identification of 2-aminoimidazole (2-AI) based AGE inhibitors and breakers, we now report the use of a rapid, scalable, two-step procedure to access a second generation of 2-AI based anti-AGE compounds from commercially available amino acids. Several second generation compounds exhibit increased AGE inhibition and breaking activty compared to the first generation compounds and to the known AGE inhibitor aminoguanidine.
- Subjects :
- Glycation End Products, Advanced
Molecular Structure
Chemistry
Organic Chemistry
Clinical Biochemistry
Imidazoles
Pharmaceutical Science
Biochemistry
First generation
Article
chemistry.chemical_compound
Structure-Activity Relationship
Glycation
Drug Discovery
Molecular Medicine
Advanced glycation end-product
Molecular Biology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....75dc683a104296a3cbd2d4cf3aefeba3