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Effects of hydrophobicity and mat thickness on release from hydrogel-electrospun fiber mat composites
- Source :
- Journal of Biomaterials Science, Polymer Edition. 24:2018-2030
- Publication Year :
- 2013
- Publisher :
- Informa UK Limited, 2013.
-
Abstract
- Poly(ethylene glycol) (PEG)-based hydrogel-electrospun fiber mat (EFM) composites are a promising new controlled release system for hydrophilic drugs, providing longer and more linear release characteristics accompanied by a smaller initial burst than traditional hydrogel systems. However, the effect of EFM properties on release characteristics has not yet been examined. Here, we investigated the influence of EFM thickness and hydrophobicity on swelling and release behavior using bovine serum albumin as a model hydrophilic protein. EFMs investigated were comprised of poly(ε-caprolactone) (PCL) at thicknesses of 300, 800, or 1100 μm. Hydrophobicity was adjusted through surface modification: fluorinated PCL, core/shell PCL/PEGPCL, and acrylic acid (AAc)-treated PCL EFMs were examined. EFMs comprised of the external composite surface, forming a sandwich around PEG-poly(lactic acid) (PEGPLA) hydrogels, and significantly restrained hydrogel swelling in the radial direction while increasing swelling in the axial direction. Incorporation of EFMs also reduced initial hydrophilic protein release rates and extended the duration of release. Increased EFM thickness and hydrophobicity were equally correlated with longer and more linear release profiles. Increased thickness most likely increases the diffusional path length, whereas increased hydrophobicity hinders hydrophilic drug diffusion. These composites form a promising new class of tunable release materials having properties superior to those of unmodified hydrogels.
- Subjects :
- Materials science
Biomedical Engineering
Biophysics
Bioengineering
macromolecular substances
Polyethylene Glycols
Biomaterials
chemistry.chemical_compound
PEG ratio
medicine
Animals
Nanotechnology
Fiber
Composite material
Acrylic acid
Drug Carriers
technology, industry, and agriculture
Hydrogels
Serum Albumin, Bovine
Controlled release
Kinetics
chemistry
Delayed-Action Preparations
Self-healing hydrogels
Surface modification
Cattle
Swelling
medicine.symptom
Hydrophobic and Hydrophilic Interactions
Ethylene glycol
Subjects
Details
- ISSN :
- 15685624 and 09205063
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Biomaterials Science, Polymer Edition
- Accession number :
- edsair.doi.dedup.....75d94e47c8e22c04bd527cdb410bcf8a
- Full Text :
- https://doi.org/10.1080/09205063.2013.822246