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Structural and functional changes in the brain of patients with Crohn’s disease: an activation likelihood estimation meta-analysis
- Source :
- Brain Imaging and Behavior. 15:807-818
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Multiple reports for brain functional and structural alterations in patients with Crohn's disease (CD) were published. The current study aimed to meta-analyze the existing neuroimaging data and hence produce a brain map revealing areas with functional and structural differences between patients with CD and healthy controls. Original studies published until 2019 were identified from Scopus, Web of Science and PubMed databases, and included into the analysis if they reported relevant results from task-related or resting state functional magnetic resonance imaging (fMRI or rsfMRI) or voxel-based morphometry (VBM), in the form of standardized brain coordinates based on whole-brain analysis. The brain coordinates and sample size of significant results were extracted from eligible studies to be meta-analyzed with the activation likelihood estimation method using the GingerALE software. Sixteen original studies comprised of a total of 865 participants fulfilled the inclusion criteria. Compared to healthy controls, patients with CD had reduced resting state brain connectivity in the paracentral lobule and cingulate gyrus as well as reduced grey matter volume in the medial frontal gyrus. No significant results were found vice versa. These neural correlates allow a better understanding on the effects of CD on the pain expectation, emotion, and quality of life of patients and potentially serve as useful biomarkers for evaluating treatment efficacy.
- Subjects :
- Oncology
medicine.medical_specialty
Cognitive Neuroscience
Grey matter
Brain mapping
050105 experimental psychology
03 medical and health sciences
Behavioral Neuroscience
Cellular and Molecular Neuroscience
0302 clinical medicine
Crohn Disease
Neuroimaging
Gyrus
Internal medicine
Humans
Medicine
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
Paracentral lobule
Likelihood Functions
Resting state fMRI
business.industry
05 social sciences
Neuropsychology
Brain
Medial frontal gyrus
Magnetic Resonance Imaging
Psychiatry and Mental health
medicine.anatomical_structure
Neurology
Quality of Life
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 19317565 and 19317557
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Brain Imaging and Behavior
- Accession number :
- edsair.doi.dedup.....75cee1eb7fb6466e6919b07f5fcb31d0