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Comparison of the cytotoxic effects of enantiopure PPAPs, including nemorosone and clusianone
- Source :
- Bioorganicmedicinal chemistry letters. 22(19)
- Publication Year :
- 2012
-
Abstract
- The synthesis of an unnatural polyprenylated acylphloroglucinol (PPAP), regioisomeric with nemorosone and clusianone, has been accomplished. The separated enantiomers of this new PPAP, along with those of nemorosone and clusianone, have been screened for activity against HeLa (cervix carcinoma), MIA-PaCa-2 (pancreatic carcinoma), and MCF7 (mamma carcinoma) cancer cell lines. All of the isomers examined gave surprisingly similar results in the screens.
- Subjects :
- endocrine system diseases
Stereochemistry
Clinical Biochemistry
Molecular Conformation
Pharmaceutical Science
Stereoisomerism
Antineoplastic Agents
Biochemistry
HeLa
Benzophenones
Bridged Bicyclo Compounds
Structure-Activity Relationship
Cell Line, Tumor
Drug Discovery
Benzoquinones
Cytotoxic T cell
Structure–activity relationship
Humans
Nemorosone
Molecular Biology
biology
Dose-Response Relationship, Drug
Chemistry
Organic Chemistry
biology.organism_classification
Enantiopure drug
MCF-7 Cells
Molecular Medicine
Enantiomer
Drug Screening Assays, Antitumor
Clusianone
HeLa Cells
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 22
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....75ce51c43e16341808ad00243a6bd1a3