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The effect of pregnancy on paternal skin allograft survival
- Source :
- Science in China Series C: Life Sciences. 52:1011-1015
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- Elucidation of maternal-fetal tolerance mechanisms clarifies the role of regulatory T cells (Treg) in transplant tolerance. This study aim to investigate the effect of pregnancy on paternal skin allograft survival. Flow cytometry techniques, mixed lymphocytes reaction (MLR), PCR, real-time PCR and skin transplantation were key methods. Treg increased significantly from 4.2% before pregnancy to peak at 6.8% day 8 after pregnancy. Both heme oxygenase-1 (HO-1) and indoleamine 2,3-dioxygenase (IDO) mRNA express high in placenta while low in spleen (P
- Subjects :
- Male
Placenta
chemical and pharmacologic phenomena
Spleen
T-Lymphocytes, Regulatory
General Biochemistry, Genetics and Molecular Biology
Flow cytometry
Mice
chemistry.chemical_compound
Pregnancy
Allograft survival
Immune Tolerance
medicine
Splenocyte
Animals
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase
Transplantation, Homologous
Heme
Skin
General Environmental Science
Mice, Inbred BALB C
Messenger RNA
medicine.diagnostic_test
business.industry
Graft Survival
Membrane Proteins
Skin Transplantation
Flow Cytometry
medicine.disease
Lymphocyte Subsets
Mice, Inbred C57BL
medicine.anatomical_structure
chemistry
Immunology
Female
General Agricultural and Biological Sciences
business
Heme Oxygenase-1
Subjects
Details
- ISSN :
- 18622798 and 10069305
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Science in China Series C: Life Sciences
- Accession number :
- edsair.doi.dedup.....75ce44554577ec701a595602bd1e80b4