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Case report: An HIV+ patient presenting with pancytopenia, hepatic failure, and coagulopathy; a rare small cell liver carcinoma with diffuse splenic and bone marrow metastasis diagnosed at autopsy
- Source :
- Experimental and molecular pathology. 103(2)
- Publication Year :
- 2017
-
Abstract
- A 34-year old male with a giant condyloma acuminatum of the anus secondary to HIV infection presented to the emergency department with a persistent nose bleed lasting 2-3days, acute anemia, thrombocytopenia, and coagulopathy. The patient also had significant hepatosplenomegaly and elevated liver enzymes which were a new finding since the patient's last hospitalization 1-2month prior to the current admission. A bone marrow biopsy showed diffuse infiltration by carcinoma with neuroendocrine features. The patient quickly developed multi-organ injury, decompensated, and died. An autopsy was obtained which established the diagnosis of small cell carcinoma of the liver.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Lung Neoplasms
Pancytopenia
Clinical Biochemistry
Hepatosplenomegaly
Autopsy
HIV Infections
Small-cell carcinoma
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Fatal Outcome
Coagulopathy
medicine
Carcinoma
Humans
Molecular Biology
Giant condyloma acuminatum
business.industry
Splenic Neoplasms
Blood Coagulation Disorders
medicine.disease
Small Cell Lung Carcinoma
medicine.anatomical_structure
030220 oncology & carcinogenesis
HIV-1
030211 gastroenterology & hepatology
Bone marrow
medicine.symptom
business
Bone Marrow Neoplasms
Liver Failure
Subjects
Details
- ISSN :
- 10960945
- Volume :
- 103
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Experimental and molecular pathology
- Accession number :
- edsair.doi.dedup.....75cbda3dd8855cc9f079c83d3d2476fa