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IN VITRO SUSCEPTIBILITY OF SHIGELLAE TO SODIUM SULFADIAZINE AND TO EIGHT ANTIBIOTICS
- Source :
- JAMA. 193
- Publication Year :
- 1965
-
Abstract
- More than 300 recently isolated Shigella strains were tested for susceptibility, to sodium sulfadiazine by tube and plate dilution techniques. With a low inoculum (100 organisms), 59% of Shigella flexneri and 87% of S sonnei were sulfadiazine resistant. All strains were resistant by high inoculum testing (2 × 10 6 organisms). Antibiotic susceptibility testing by the plate dilution method using high inocula demonstrated by the following percentages of resistance: potassium penicillin G, 93%; streptomycin, 17%; tetracycline hydrochloride, 12%; chloramphenicol, 11%; ampicillin, 6%; sodium colistimethate, 2%; kanamycin sulfate, 1%; and neomycin sulfate, 1%. These studies indicate that sulfadiazine is no longer an appropriate drug for initiating treatment of shigellosis. Ampicillin and three orally administered non-absorbable antibiotics (colistimethate, kanamycin and neomycin) are the most effective drugs against shigellae in vitro.
- Subjects :
- Drug Resistance
Sulfadiazine
Bacillus
In Vitro Techniques
Benzylpenicillin
Microbiology
Dysentery
Shigella flexneri
Kanamycin
Ampicillin
medicine
Dysentery, Bacillary
Pharmacology
Bacteriological Techniques
biology
business.industry
Research
Sodium
Drug Resistance, Microbial
Neomycin
Penicillin G
General Medicine
biochemical phenomena, metabolism, and nutrition
Tetracycline
biology.organism_classification
Anti-Bacterial Agents
Chloramphenicol
Streptomycin
Shigella
business
medicine.drug
Colistimethate
Subjects
Details
- ISSN :
- 00987484
- Volume :
- 193
- Database :
- OpenAIRE
- Journal :
- JAMA
- Accession number :
- edsair.doi.dedup.....75c145114e8dc5e019a12d4c4bb9d0a1