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Functions of Presynaptic Voltage-gated Calcium Channels
- Source :
- Function (Oxford, England)
- Publication Year :
- 2020
-
Abstract
- Voltage-gated calcium channels are the principal conduits for depolarization-mediated Ca2+ entry into excitable cells. In this review, the biophysical properties of the relevant members of this family of channels, those that are present in presynaptic terminals, will be discussed in relation to their function in mediating neurotransmitter release. Voltage-gated calcium channels have properties that ensure they are specialized for particular roles, for example, differences in their activation voltage threshold, their various kinetic properties, and their voltage-dependence of inactivation. All these attributes play into the ability of the various voltage-gated calcium channels to participate in different patterns of presynaptic vesicular release. These include synaptic transmission resulting from single action potentials, and longer-term changes mediated by bursts or trains of action potentials, as well as release resulting from graded changes in membrane potential in specialized sensory synapses.
- Subjects :
- 0301 basic medicine
AcademicSubjects/SCI01360
Neurotransmission
voltage-gated
Synapse
biophysical properties
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
synapse
Evidence Review
Neurotransmitter
presynaptic terminal
Membrane potential
AcademicSubjects/SCI01270
Voltage-gated ion channel
Voltage-dependent calcium channel
Calcium channel
030104 developmental biology
second messenger
chemistry
auxiliary subunit
Second messenger system
Biophysics
molecular properties
AcademicSubjects/SCI00960
AcademicSubjects/MED00772
calcium channel
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 26338823
- Volume :
- 2
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Function (Oxford, England)
- Accession number :
- edsair.doi.dedup.....75bf455b271d62d26585cafd32e12018