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Characterization of β-Lactotensin, a Bioactive Peptide Derived from Bovine β-Lactoglobulin, as a Neurotensin Agonist
- Source :
- Bioscience, Biotechnology, and Biochemistry. 67:940-943
- Publication Year :
- 2003
- Publisher :
- Informa UK Limited, 2003.
-
Abstract
- beta-Lactotensin (beta-LT: His-Ile-Arg-Leu) is an ileum-contracting peptide derived from residues No. 146-149 of bovine beta-lactoglobulin. The ileum-contracting activity of beta-LT was blocked by the NT1 antagonist SR48692. beta-LT was selective for the neurotensin NT2 receptor while neurotensin was selective for the NT1 receptor. beta-LT is the first natural ligand showing selectivity for the NT2 receptor. beta-LT showed hypertensive activity after intravenous administration at a dose of 30 mg/kg in conscious rats, while neurotensin showed hypotensive activity. The hypertensive activity of beta-LT was blocked by levocabastine (1 mg/kg, i.v.), an NT2 antagonist. SR48692, which blocked the hypotensive activity of neurotensin, had no effect on the hypertensive activity of beta-LT. These results suggest that the hypertensive activity of beta-LT is mediated by the NT2 receptor. It was concluded that the NT1 and NT2 receptors mediate the opposite effect on blood pressure.
- Subjects :
- Male
Agonist
medicine.medical_specialty
medicine.drug_class
Guinea Pigs
Blood Pressure
Peptide
Lactoglobulins
Applied Microbiology and Biotechnology
Biochemistry
Analytical Chemistry
chemistry.chemical_compound
Bioactive peptide
Ileum
Internal medicine
medicine
Animals
Humans
Receptors, Neurotensin
Rats, Wistar
Receptor
Molecular Biology
Neurotensin
chemistry.chemical_classification
digestive, oral, and skin physiology
Organic Chemistry
Antagonist
General Medicine
Ligand (biochemistry)
Levocabastine
Rats
Endocrinology
chemistry
Cattle
Oligopeptides
Muscle Contraction
Biotechnology
medicine.drug
Subjects
Details
- ISSN :
- 13476947 and 09168451
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Bioscience, Biotechnology, and Biochemistry
- Accession number :
- edsair.doi.dedup.....759fbea66ab23cecf89b91794db42626