CXCR1/CXCR2 Antagonism Is Effective in Pulmonary Defense againstKlebsiella pneumoniaeInfection

Klebsiella pneumoniae-associated pathology is largely mediated by neutrophilic inflammation. In this study, we administeredKlebsiella pneumoniaeto experimental guinea pig groups and the ELR-CXC chemokine antagonistCXCL83–72, ceftazidime, and dexamethasone to different groups, respectively. After 24 h, we assessed the animal’s pulmonary inflammatory levels, including gross histopathology, airway neutrophilia, lung myeloperoxidase levels, expressions of CXCL8 and TNF, and airway bacterial loads. Compared with ceftazidime and dexamethasone treatments, the administration of the ELR-CXC chemokine antagonistCXCL83–72alone was more effective than other methods, although it did not markedly attenuate the bacterial load. These results suggest new methods for the treatment ofKlebsiella pneumoniaepathology.