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Reovirus type 3 binds to antagonist domains of the beta-adrenergic receptor
- Source :
- Journal of Virology. 64:639-641
- Publication Year :
- 1990
- Publisher :
- American Society for Microbiology, 1990.
-
Abstract
- Reovirus type 3 interfered with the binding of beta-adrenergic antagonist ligands to receptors on Y1 adrenal, C6 glioma, and mouse L cells. This inhibition of beta-adrenergic binding was dose related. Reovirus did not interfere with dopaminergic binding or isoproterenol-induced activation of adenylate cyclase. In addition, reovirus infected Y1 cells, which bind beta-adrenergic antagonist ligands but lack agonist-induced activity. These results suggest that reovirus infection is initiated by binding to antagonist (nonfunctional) domains of the adrenergic receptor complex.
- Subjects :
- medicine.medical_specialty
Adrenergic receptor
viruses
Immunology
Adrenal Gland Neoplasms
Adenylate kinase
Biology
Reoviridae
Binding, Competitive
Microbiology
Cyclase
Mice
chemistry.chemical_compound
L Cells
Virology
Internal medicine
Receptors, Adrenergic, beta
medicine
Animals
Receptor
Mammalian orthoreovirus 3
Isoproterenol
Antagonist
Biological activity
Glioma
Molecular biology
Kinetics
Endocrinology
chemistry
Spiperone
Dihydroalprenolol
Competitive antagonist
Insect Science
Research Article
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....7587f601bd9d20e136856b5122a93faf