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Soluble urokinase receptor and focal segmental glomerulosclerosis
- Source :
- Current Opinion in Nephrology and Hypertension. 21:428-432
- Publication Year :
- 2012
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2012.
-
Abstract
- Purpose of review We discuss recent work on the pathogenetic mechanism of focal segmental glomerulosclerosis (FSGS) and its relationship to soluble urokinase receptor (suPAR). Recent findings Primary FSGS can affect both children and adults. The disease can recur after kidney transplantation suggesting the involvement of a causative circulating factor. Recent work suggests that approximately two-thirds of FSGS patients have elevated levels of serum suPAR, which confers risk to both native and posttransplant FSGS. Summary Future studies that are geared to understand the clinical implications of high suPAR levels in native FSGS as well as in the pretransplant and posttransplant setting will allow for better patient risk stratification and more targeted treatment options.
- Subjects :
- Oncology
Integrins
medicine.medical_specialty
Future studies
Kidney Glomerulus
Disease
urologic and male genital diseases
Risk Assessment
Receptors, Urokinase Plasminogen Activator
Primary FSGS
Focal segmental glomerulosclerosis
Recurrence
Risk Factors
Internal medicine
Internal Medicine
medicine
Animals
Humans
Kidney transplantation
Glomerulosclerosis, Focal Segmental
Podocytes
urogenital system
business.industry
Glomerulosclerosis
medicine.disease
Kidney Transplantation
female genital diseases and pregnancy complications
Up-Regulation
Urokinase receptor
Treatment Outcome
SuPAR
Nephrology
business
Subjects
Details
- ISSN :
- 10624821
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Nephrology and Hypertension
- Accession number :
- edsair.doi.dedup.....7585f4c1ca0b8d65d7f5e865e278e8bd