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Adiposity, related biomarkers, and type 2 diabetes after gestational diabetes: The Diabetes Prevention Program
- Source :
- Obesity (Silver Spring)
- Publication Year :
- 2021
-
Abstract
- Objective: This study investigated associations of adiposity and adiposity-related biomarkers with incident type 2 diabetes (T2D) among parous women. Methods: Among women in the Diabetes Prevention Program (DPP) who reported a previous live birth, circulating biomarkers (leptin, adiponectin, sex hormone-binding globulin, and alanine aminotransferase; n = 1,711) were measured at enrollment (average: 12 years post partum). Visceral (VAT) and subcutaneous adipose tissue areas at the L2-L3 region and the L3-L4 region were quantified by computed tomography (n = 477). Overall and stratified (by history of gestational diabetes mellitus [GDM]) adjusted Cox proportional hazards models were fit. Results: Alanine aminotransferase, L2-L3 VAT, and L3-L4 VAT were positively associated (hazard ratio [HR] for 1-SD increases: 1.073, p = 0.024; 1.251, p = 0.009; 1.272, p = 0.004, respectively), and adiponectin concentration was inversely associated with T2D (HR 0.762, p < 0.001). Whereas leptin concentration was not associated with T2D overall, in GDM-stratified models, a 1-SD higher leptin was positively associated with risk of T2D in women without GDM (HR: 1.126, p = 0.016) and inversely in women with a history of GDM (HR: 0.776, p = 0.013, interaction p = 0.002). Conclusions: Among parous women, alanine aminotransferase and VAT are positively associated with incident T2D, whereas adiponectin is inversely associated. Leptin is associated with higher risk of T2D in women with a history of GDM but a lower risk in women without a history of GDM. © 2021 The Obesity Society (TOS). This article has been contributed to by US Government employees and their work is in the public domain in the USA.
- Subjects :
- medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Type 2 diabetes
Lower risk
Medical and Health Sciences
Article
Endocrinology
Pregnancy
Diabetes mellitus
Internal medicine
Health Sciences
Diabetes Mellitus
medicine
Humans
Obesity
Adiposity
Nutrition and Dietetics
Adiponectin
Proportional hazards model
business.industry
Leptin
Diabetes
Hazard ratio
nutritional and metabolic diseases
medicine.disease
Gestational diabetes
Diabetes, Gestational
Diabetes Mellitus, Type 2
Gestational
Female
business
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Obesity (Silver Spring)
- Accession number :
- edsair.doi.dedup.....75821cb5394040a00d70ee6197b64717