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Purinergic Signaling: A Common Path in the Macrophage Response against Mycobacterium tuberculosis and Toxoplasma gondii
- Source :
- Frontiers in Cellular and Infection Microbiology, Frontiers in Cellular and Infection Microbiology, 2017, 7, pp.347. ⟨10.3389/fcimb.2017.00347⟩, Frontiers in Cellular and Infection Microbiology, Vol 7 (2017), Frontiers in Cellular and Infection Microbiology, Frontiers, 2017, 7, pp.347. ⟨10.3389/fcimb.2017.00347⟩
- Publication Year :
- 2017
- Publisher :
- Frontiers Media S.A., 2017.
-
Abstract
- International audience; Immune responses are essential for the protection of the host against external dangers or infections and are normally efficient in the clearance of invading microbes. However, some intracellular pathogens have developed strategies to replicate and survive within host cells resulting in latent infection associated with strong inflammation. This excessive response can cause cell and tissue damage and lead to the release of the intracellular content, in particular the nucleotide pool, into the extracellular space. Over the last decade, new studies have implicated metabolites from the purinergic pathway in shaping the host immune response against intracellular pathogens and proved their importance in the outcome of the infection. This review aims to summarize how the immune system employs the purinergic system either to fight the pathogen, or to control collateral tissue damage. This will be achieved by focusing on the macrophage response against two intracellular pathogens, the human etiologic agent of tuberculosis, Mycobacterium tuberculosis and the protozoan parasite, Toxoplasma gondii.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Immunology
lcsh:QR1-502
Toxoplasma gondii
Microbiology
lcsh:Microbiology
03 medical and health sciences
Immune system
Purinergic Agents
Macrophage
innate immunity
Innate immune system
biology
Intracellular parasite
Purinergic receptor
Mycobacterium tuberculosis
biology.organism_classification
purinergic agents
nucleotides
3. Good health
macrophages
ATP
030104 developmental biology
Infectious Diseases
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
[SDV.IMM]Life Sciences [q-bio]/Immunology
Intracellular
Subjects
Details
- Language :
- English
- ISSN :
- 22352988
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Frontiers in Cellular and Infection Microbiology
- Accession number :
- edsair.doi.dedup.....757cb985c381d546afa00e2d0de56920
- Full Text :
- https://doi.org/10.3389/fcimb.2017.00347