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Probucol reduces hepatic cholesterol secretion in hyperlipidemic Yoshida rats
- Source :
- Atherosclerosis. 119:223-233
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- In this study, perfused livers from Yoshida rats, either on a normal diet or on a diet with 0.3% probucol, were examined. The analysis of liver lipid content and of bile and lipoprotein secretion changes showed that probucol had a relevant effect on liver lipid biosynthesis. In particular, it reduced the production of triacylglycerols and, to a much greater extent that of cholesterol. In addition, probucol reduced plasma cholesterol concentration by decreasing esterified cholesterol in HDL1 and HDL2 fractions. Furthermore, HDL1 composition of both hepatic neosynthetized and circulating particles was strongly modified by probucol. Finally, probucol did not appear to induce significant differences in lipid bile secretion while phospholipid secretion from perfused livers was increased. These facts suggest that the hypolipidemic action of probucol is not mediated by an increase in bile steroid secretion, but rather by a direct reduction in hepatic lipoprotein cholesterol secretion. This secretion induces a modified plasma profile of HDL particles such that these variations are advantageous in terms of reverse cholesterol transport.
- Subjects :
- Male
medicine.medical_specialty
Very low-density lipoprotein
Normal diet
Lipoproteins
Probucol
Hyperlipidemias
Rats, Mutant Strains
chemistry.chemical_compound
Internal medicine
medicine
Animals
Bile
Cholesterol
Anticholesteremic Agents
Body Weight
Cholesterol, HDL
Reverse cholesterol transport
Lipids
Rats
Endocrinology
Liver
chemistry
Low-density lipoprotein
Cholesteryl ester
lipids (amino acids, peptides, and proteins)
Cholesterol Esters
Cardiology and Cardiovascular Medicine
medicine.drug
Lipoprotein
Subjects
Details
- ISSN :
- 00219150
- Volume :
- 119
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....7579f33d62f186642a49f043f22fe40e