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Immunohistochemical detection of p53 and c-erbB-2 in oesophageal carcinoma; no correlation with prognosis
Immunohistochemical detection of p53 and c-erbB-2 in oesophageal carcinoma; no correlation with prognosis
- Source :
- European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 23(1)
- Publication Year :
- 1997
-
Abstract
- TNM staging of oesophageal cancer provides significant prognostic information but its clinical impact is limited as many patients present with advanced disease (i.e. T3N1). Additional prognostic markers may help separate those with 'good' and 'bad' prognosis tumours and so help with decisions such as selection for adjuvant therapy. p53 and c-erbB-2 overexpression may correlate with poor prognosis in oesophageal cancer, but this is uncertain. This study aimed to investigate the value of these biomarkers as prognostic indicators in resected oesophageal cancer. Two hundred and five oesophageal tumours (127 adenocarcinoma, 78 squamous) resected by a single surgeon between June 1979 and January 1991 were investigated for p53 and c-erbB-2 overexpression using DO-7 and CB-11 immunohistochemistry. Patient survival was analysed by Kaplan-Meir life tables. Median survival was 61 weeks (range: 5-747) and survival diminished significantly with increasing UICC stage (P < 0.0001). Sixty-eight per cent of squamous tumours and 66% of adenocarcinomas overexpressed p53 but there was no statistically significant correlation with prognosis. Twenty-six per cent of squamous tumours and 23% of adenocarcinomas overexpressed c-erbB-2, but again this did not correlate with survival. p53 and c-erbB-2 are commonly overexpressed in oesophageal cancer but do not appear to be related to prognosis in this large series of resected oesophageal cancers and other candidate biomarkers must be sought.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Pathology
Esophageal Neoplasms
Receptor, ErbB-2
Adenocarcinoma
Internal medicine
Carcinoma
medicine
Adjuvant therapy
Humans
Esophagus
Survival analysis
Aged
Aged, 80 and over
business.industry
Esophageal disease
Cancer
General Medicine
Middle Aged
medicine.disease
Prognosis
Immunohistochemistry
Survival Analysis
medicine.anatomical_structure
Carcinoma, Squamous Cell
Surgery
Female
Tumor Suppressor Protein p53
business
Subjects
Details
- ISSN :
- 07487983
- Volume :
- 23
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....7570fc413a50e0d6b90868990a369513