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Effective doses of cisatracurium in the adult and the elderly
- Source :
- Korean Journal of Anesthesiology, Korean Journal of Anesthesiology, Vol 69, Iss 5, Pp 453-459 (2016)
- Publication Year :
- 2016
- Publisher :
- The Korean Society of Anesthesiologists, 2016.
-
Abstract
- Background There are few information about the differences of the effective dose (ED) of cisatracurium between the adult and the elderly. We investigated the ED and the onset time of cisatracurium in the adults and the elderly. Methods We studied two hundred patients of the adults aged 20 through 64 years and the elderly aged ≥ 65 years, with American Society of Anesthesiologists physical status I or II. Each 100 patients with 20 patients of each dose group, randomly selected from 30, 40, 50, 60 or 70 µg/kg of cisatracurium, were randomly allocated to the adults and the elderly groups. We recorded the 0.1 Hz single twitch responses of the adductor pollicis and the onset times to maximal blockade. The magnitude of muscle relaxation was recorded by using an acceleromyography. The effect of cisatracurium on single twitch was calculated as percent reduction. After converting each drug dose into logarithm and percent reduction of the muscle reduction into probit, the EDs representing the muscle relaxation effects of 5%, 25%, 50%, 75% and 95% were estimated using the linear regression analysis. Results No significant differences were found in age, weight, height, or body mass index within or between the groups. The ED50 and ED95 of the adult group were 35.39 and 59.58 µg/kg. The ED50 and ED95 of the elderly group were 34.89 and 55.50 µg/kg, respectively. The onset times were 375.4 ± 76.9 seconds in the adult group and 369.1 ± 70.0 seconds in the elderly group. Conclusions The ED and the onset time were not significantly different between the adult and the elderly.
- Subjects :
- Clinical Research Article
business.industry
Effective dose (pharmacology)
lcsh:RD78.3-87.3
03 medical and health sciences
0302 clinical medicine
Anesthesiology and Pain Medicine
Muscle relaxation
lcsh:Anesthesiology
030202 anesthesiology
Anesthesia
Cisatracurium
Dose group
Adductor pollicis
Medicine
030212 general & internal medicine
business
Body mass index
Aged
American society of anesthesiologists
Subjects
Details
- ISSN :
- 20057563 and 20056419
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Korean Journal of Anesthesiology
- Accession number :
- edsair.doi.dedup.....756bbb2851311294a266aeac22607ef4