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Studying the Immune Synapse in HIV-1 Infection
- Source :
- Methods in Molecular Biology, Methods in Molecular Biology, Volume 1584, pp.545-557, 2017, springer protocols-The Immune Synapse : methods and protocols, ⟨10.1007/978-1-4939-6881-7_34⟩, The Immune Synapse ISBN: 9781493968794
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- International audience; T cells are the main cellular targets of the human immunodeficiency virus 1 (HIV-1). HIV-1 infection induces pleiotropic effects on the infected T cell that modify the T cell capacity to respond to antigen and facilitates virus replication. HIV-1 infection subverts the formation and function of the immunological synapse altering both actin cytoskeleton remodeling and intracellular vesicle traffic. We describe here our methods to unveil how HIV-1 and in particular its protein Nef modify vesicle traffic to the immunological synapse, perturbing the synapse activation capacity.
- Subjects :
- 0301 basic medicine
Immunological Synapses
HIV Antigens
Endosome
T cell
HIV Infections
Endosomes
[SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]
Biology
Virus Replication
Immunological synapse
Synapse
TCR signaling
Jurkat Cells
03 medical and health sciences
Antigen
[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]
medicine
Humans
Vesicle traffic
nef Gene Products, Human Immunodeficiency Virus
Cytoskeleton
Nef
T cell activation
virus diseases
Intracellular vesicle
3. Good health
Cell biology
030104 developmental biology
medicine.anatomical_structure
Viral replication
Immunology
HIV-1
Subjects
Details
- Language :
- English
- ISBN :
- 978-1-4939-6879-4
- ISBNs :
- 9781493968794
- Database :
- OpenAIRE
- Journal :
- Methods in Molecular Biology, Methods in Molecular Biology, Volume 1584, pp.545-557, 2017, springer protocols-The Immune Synapse : methods and protocols, ⟨10.1007/978-1-4939-6881-7_34⟩, The Immune Synapse ISBN: 9781493968794
- Accession number :
- edsair.doi.dedup.....7560f41e382fb629c13721b3f57c6866