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The potential of neural stem cells to repair stroke-induced brain damage
- Source :
- Acta neuropathologica. 117(5)
- Publication Year :
- 2008
-
Abstract
- Acute injuries to CNS such as stroke induce neural progenitor proliferation in adult brain which might be an endogenous attempt to self-repair. This process is known to be altered by several exogenous and endogenous modulators including growth factors that could help to reinforce the post-stroke neurogenesis. Increasing the neurogenesis may be a future therapeutic option to decrease the cognitive and behavioral deficits following stroke. In addition, transplantation of various types of stem cells into the injured brain is currently thought to be an exciting option to replace the neurons lost in the post-ischemic brain. These include immortalized stem cell lines, neural progenitors prepared from embryonic and adult animals and mesenchymal stem cells. Using exogenous stem cells in addition to modulating endogenous neurogenesis, we may be able to repair the injured brain after a devastating stroke. This article reviewed the current literature of these two issues.
- Subjects :
- Neurogenesis
Clinical uses of mesenchymal stem cells
Brain damage
Biology
Pathology and Forensic Medicine
Cellular and Molecular Neuroscience
medicine
Animals
Humans
Progenitor cell
Mental Disorders
Anatomy
Recovery of Function
Neural stem cell
Neuroepithelial cell
Stroke
Treatment Outcome
Brain Injuries
Neurology (clinical)
medicine.symptom
Stem cell
Cognition Disorders
Neuroscience
Adult stem cell
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 14320533
- Volume :
- 117
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Acta neuropathologica
- Accession number :
- edsair.doi.dedup.....7560b0cf623349975fd3c93bd442bf24