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Vincristine-induced allodynia in the rat
- Source :
- Pain. 93:69-76
- Publication Year :
- 2001
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2001.
-
Abstract
- The aims of this study were two-fold: first, to simplify the method for creating a recently described neuropathic pain model in the rat, and second, to evaluate the effects of a number of drugs with analgesic or antihyperalgesic properties, in this model. Continuous intravenous vincristine infusion (1-100 microg kg(-1) day (-1)) for 14 days resulted in a dose dependent tactile allodynia (as measured by von Frey filaments) by 7 days at doses between 30 - 100 microg kg(-1) day (-1), with a hindlimb motor deficit observed at doses greater than 50 microg kg(-1) day (-1). No thermal hyperalgesia was observed. Systemic morphine, lidocaine, mexiletine and pregabalin (given intraperitoneally) produced significant reduction of the allodynia, while tetrodotoxin was without effect. Continuous intravenous infusion of vincristine in rats thus provides a reliable model of chemotherapy induced neuropathy which may be used in defining the mechanism and pharmacology of this clinically relevant condition.
- Subjects :
- Male
Pain Threshold
Vincristine
Hot Temperature
Cyclohexanecarboxylic Acids
Gabapentin
Analgesic
Pregabalin
Pain
Tetrodotoxin
Acetates
Rats, Sprague-Dawley
medicine
Animals
Amines
gamma-Aminobutyric Acid
Pain Measurement
Analgesics
business.industry
Body Weight
Antineoplastic Agents, Phytogenic
Rats
Anesthesiology and Pain Medicine
Allodynia
Neurology
Anesthesia
Hyperalgesia
Neuropathic pain
Morphine
Neurology (clinical)
medicine.symptom
business
Excitatory Amino Acid Antagonists
Ion Channel Gating
medicine.drug
Subjects
Details
- ISSN :
- 03043959
- Volume :
- 93
- Database :
- OpenAIRE
- Journal :
- Pain
- Accession number :
- edsair.doi.dedup.....75595219c8cc728de4c2daf166afd00a