Significance of the binding ability of hemopoietic microenvironment cells for restoration of individual hemopoietic stem precursors suppressed by cytostatic drugs

Restoration of granulomonocytopoiesis in CBA mice treated with maximum tolerated doses of adriamycin or cyclophosphane is strongly dependent on the maturation of precursor cells. Accelerated maturation is provided by the binding of the microenvironment cells to stem precursor cells. Restoration of erythroid precursors damaged by cytostatics is slower in the absence of such a binding.