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A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines
- Source :
- SynOpen, Vol 05, Iss 01, Pp 43-48 (2021)
- Publication Year :
- 2021
- Publisher :
- Thieme Open, 2021.
-
Abstract
- A highly efficient and catalyst-free protocol is reported for the synthesis of quinoxalines via the classical cyclocondensation reaction between aryldiamines and dicarbonyl compounds. Remarkably simple and green reaction conditions employing methanol as solvent afforded medium to excellent yield of quinoxalines after only one-minute reaction time at ambient temperature. The conditions allow at least 10 gram scale synthesis of quinoxalines and should be a preferred starting point for optimization and method of choice for applications in the synthetic community.
- Subjects :
- Materials Science (miscellaneous)
010402 general chemistry
01 natural sciences
Catalysis
lcsh:Chemistry
Biomaterials
chemistry.chemical_compound
Quinoxaline
green
quinoxaline
Diamine
diamine
Diketone
VDP::Mathematics and natural science: 400::Chemistry: 440
010405 organic chemistry
Organic Chemistry
Condensation
diketone
Combinatorial chemistry
0104 chemical sciences
Solvent
condensation
lcsh:QD1-999
chemistry
VDP::Matematikk og Naturvitenskap: 400::Kjemi: 440
Yield (chemistry)
Methanol
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- SynOpen, Vol 05, Iss 01, Pp 43-48 (2021)
- Accession number :
- edsair.doi.dedup.....7542f50b4895eee25edf6a7118cf5ec7